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Article Selection Activity for Longitudinal Drug Information Paper


is a state of mind producing a serious, long term lowering of enjoyment of life
or inability to visualize a happy future. This disease cuts across all races,
countries and continents and therefore should be taken seriously. This
psychiatry state of mind has been the cause of most people ending their life
pre maturely. Hypericum perforatum is a herbal medicine that exerts a range of
antidepressant effects, including serotonin, noradrenaline, and dopamine
reuptake inhibition, gamma-aminobutyric acid (GABA) and L glutamate pathway
modulation, and has an interaction with the neuroendocrine system.

I Chose Article #1

main reason I chose to work with article #1 over article #2 was simply because
article 1 deals with both moderate to mild depression while in Article #2
Citation: Sarris J, Fava M, Schweitzer I, et al  (Hypericum perforatum) versus sertraline and placebo
in significance depressive disturbance: continuation data from a 26-week RCT.
Pharmacopsychiatry. 2012;45:275–278. PubMed
it deals with only significance depressive disturbance  hence it has a certain group in mind already
and is not opened to everyone.

Why I Chose This Article

first characteristic why I chose article #1 over article #2 was because of the
objective which I compared before settling on article #1.  The objectives of the 2 articles vary
immensely in article #1 the main objective is to check the similarly between its
ability to produce the desired results and endurance of Hypericum perforatum  with a tricyclic heterocyclic compound which
is used to treat depression in patients with easily provoked to not excessive
depression while in article #2 the main aim was to examine the stretching data
from a 26-week randomlly, double-blind, controlled course of SJW (LI-160) vs. sertraline
and placebo in important depressive disorder. 124 participant “responders”
prolonged medical care from week 8, all the way up to week 26.

characteristic of why I chose this article was because of how they were able to
select their participants. The method they chose to select participants was,
Women and Men were included if they were 18 years or older and found to have gentle
to controlled depression lacking increased intention to kill themselves or
homicidal conceptualization and if they satisfied ICD-10 (domestic
classification of diseases, 10th revision) standard test for a psychiatry state
of mind incident or repetive depressive disorder (ICD-10 codes F32.0 or F33.0
and F32.1 or F33.1) (Woelk 538).
All the people who took part gave their consent in written form before enrolling
in the study. Partakers were expected to have earn  ?18
on the 17 item Hamilton psychiatry state of mind position in the  scale on following  visits  without interruption to be added in the course,
the consecutive visits were supposed to be 2. A lot of measures were used to
eliminate people who were not suitable people who were sensitive to the drug,
pregnant, breastfeeding or have a life threatening disease which would have
complicated the study of the drug hence the findings which they were after was
to be pure facts.

other character why I chose this particular article was on how the statistics
were analyzed. Specific mental focus was concentrated to the plan and implementations
of such methods of the research, such as how they used an enormous sample amount
to allow vigorous statistics to be analyze. The course of action to deal with
the decomposition and the decomposition of data from people who took part who agreed
with the agreement was designed in a prospective manner.

the factors that can be considered  risky
and can lead one to depression include solitude, history of depression either
to the said individual or in the family gene, complicated grief, sleep disturbance
and poor health status. Health practitioners use Anxiety and Depression scales,
the patient health questionnaire, the Edinburg postnatal depression scale for
pregnant women and postpartum to find out if someone is sinking into
depression. The age set for screening is above 18. The earlier it is discovered
the better as it can help someone from sinking deep and loosing hope. Depression
has led to a lot of suicide and substance abuse as recently as last year the
lead singer of Linkin Park, Bennington Chester took his own life after a long
battle with depression.


is a risky health issue that needs to be addressed as we are losing a lot of
people through suicides which can be preventable, also such attacks such as
panic attacks and anxiety also lead to more suicide deaths in the world.
Awareness to depression and showering people with love and affection can come
in handy when dealing with depression. The USPSTF recommends screening and
adequate follow up of the patients by medical practitioner. A great stride has
been taken in developing drugs which help people during these hard times.






H. Comparison of St John’s wort and imipramine for treating depression:
randomised controlled trial. BMJ. 2000 Sep 2;321(7260):536-9.